(5) In APML. The risk of thrombosis has been correlated with raised white blood cell count, presence of bcr3 isoform subtype of PML/RARα and fms-like tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutations, and expression of CD2 and CD15 [17]. The gene discussed is PML; the disease is acute promyelocytic leukemia.