A prominent intratumoral cytotoxic T-cell infiltrate with up to 100 CD8+ T-cells/mm2 (Fig. 2f), frequent expression of PD1 and cytotoxic granule-associated RNA binding protein (TIA-1) (Additional file 5: Figure S1) as well as a prominent histiocytic infiltrate and tumor necrosis were noted in the majority of lesions examined. Here, PDCD1 is linked to neoplasm.