APC and posterior cortical atrophy: Hypermethylation-induced silencing of the tumor suppressor glutathione S-transferase P1 gene (GSTP1) is the most frequent DNA aberration in PCa, while promoter hypermethylation of GSTP1, RASSF1A (Ras association domain family 1 isoform A), and APC (adenomatous polyposis coli) correlates with PCa stage [33, 34].