Recent work done by our group indicated nAChRs also mediated the nicotine activation of the oncogenic YAP1 of the Hippo signaling pathway in esophageal cancer, we also found upregulation of YAP1 in esophageal cancer samples is significantly associated with the smoking history of the patients, and the effects are regulated by PKC signaling, as PKC specific inhibitor can abolish the activation of YAP1 by nicotine treatment [94] (Figures 2(a) and 2(b)). Here, YAP1 is linked to esophageal cancer.