Paliwal et al. reported that cholinergic receptor, nicotinic, alpha 3 (CHRNA3) gene encoding the α3-nAChR subunit is frequently hypermethylated and silenced in lung cancer, and DNA methylation inhibitors can cause demethylation of CHRNA3 promoter and reactivation of the gene [75]. This evidence concerns the gene CHRNA3 and lung carcinoma.