The expression of SLURP1 and SLURP2 is reduced in esophageal cancers, and exogenous expression of SLURP1 and SLURP2 in esophageal cancer cells reduced the colony forming ability of the cells in the presence of nitrosamine, also inhibiting the growth of NNK transformed keratinocytes in mouse xenograft. Here, SLURP2 is linked to esophageal cancer.