ITGAM and breast cancer: Specifically, van Deventer et al. observed that the recruitment of CD11b+Ly6C+ monocytes to the premetastatic lung enhances B16 cell metastasis [154], and Gil-Bernabé et al. demonstrated that CD11b+CD68+F4/80+ recruited macrophages establish the premetastatic niche that facilitates successful breast cancer metastasis to the lungs [155].