HGS and oral lichen planus: The downregulation of other autophagy-associated genes including HGS, ESR1, and SNCA in peripheral blood T cells of OLP patients was indicated by the array analysis. HGS encodes a protein that regulates endosomal sorting and plays a critical role in the lysosomal transport, recycling, and degradation of ubiquitinated membrane proteins in the multivesicular body, which may be a key machinery for autophagic regulation [40]. ESR1 is essential for sexual development and reproductive function and is involved in the induction of autophagy in response to toxins [41, 42].