A higher Ang-2/Ang-1 ratio was also an independent predictor of mortality in ARDS patients [131, 132], and patients with infection-related ARDS whose Ang-2 levels increased between day 0 and day 3 doubled their odds of death, suggesting that Ang-2 kinetics may be particularly valuable by reflecting evolving lung injury [34]. This evidence concerns the gene ANGPT1 and acute respiratory distress syndrome.