Given that 3rd-generation EGFR-TKIs will be more widely used in real world practice as the key treatment for advanced NSCLC in the near future, a combination therapy with 3rd-generation EGFR-TKIs and IGF1R signaling inhibitor might be an attractive treatment option for the cautious optimism toward novel EGFR-TKIs. This evidence concerns the gene IGF1R and non-small cell lung carcinoma.