In line with recent findings on lung cancer [33], NZ and - at a lesser extent ZA - lowered the activity of Ras and Ras-downstream effectors ERK1/2 (Figure 3A), the amount, phosphorylation, nuclear translocation (Figure 3B) and activity (Figure 3C) of HIF-1α, the transcription of the HIF-1α-target gene Pgp (Figure 3D) and the amount of Pgp protein (Figure 3E) in JC tumor extracts. The gene discussed is MAPK3; the disease is neoplasm.