NZ was as effective as ZA in the cell lines with low Pgp levels (i.e. MCF7, SKBR3, T74D cells) and significantly more effective than ZA in the cell lines with high Pgp levels (i.e. MDA-MB-231, JC, TUBO cells), suggesting that it was an effective chemosensitizing agent in doxorubicin-resistant breast cancer cells. Here, PGP is linked to breast carcinoma.