PFKM and neoplasm: Doxorubicin increased the mRNA levels of the HIF-1α-target genes involved in the glucose uptake and glycolytic flux, such as glucose transporter 1 (GLUT1), hexokinase (HK), phosphofructokinase-1 (PFK1), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), enolase A (ENOA), pyruvate kinase (PK) in tumor extracts (Figure 4A).