In searching approximately 100 breast cancer microarray datasets on the NCBI Gene Expression Omnibus (GEO) website, we found that a novel lncRNA, EPB41L4A-AS2, was closely associated with several vital tumor pathophysiological processes including tumorigenesis, chemoresistance, and estrogen regulation (http://www.ncbi.nlm.nih.gov/geoprofiles). The gene discussed is EPB41L4A; the disease is neoplasm.