They found that Ad-TERTp-E1A-EphA3 shRNA had 3.5- and 1,400- fold greater ability to kill EphA3 and TERT expressing tumor cells compared to Ad-TERTp-E1A-NC and Ad-ΔE1A-EphA3 shRNA, respectively, while had little effect on cells that modestly expressed EphA3 and TERT. The gene discussed is DHTKD1; the disease is neoplasm.