The present study showed that in accordance with decreased inflammasome formation in HFD fed Asm−/− mice, urinary protein excretion and glomerular injury/sclerosis were significantly blocked compared with Asm+/+ mice on the high fat diet, suggesting the contribution of ASMase to the inflammasome formation in podocytes and thereby leading to the obesity-induced glomerular injury. The gene discussed is SMPD1; the disease is Obesity.