Most recently we have demonstrated that inhibition of NLRP3 inflammasomes either by apoptosis associated speck-like protein (ASC) gene knockout or ASC gene silencing attenuated the obesity-induced glomerular injury and podocyte injury [5]; however, it remains unknown how obesity-induces Nlrp3 inflammasome activation in glomeruli. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.