Some studies indicate that miR-203 overexpression suppresses cell growth and metastasis via targeting different genes in different tumor tissues, such as targeting TBK1 in Osteosarcoma [28], ADAM9 and long non-coding RNA HULC in hepatocellular carcinoma [29], Rap1A in prostate cancer [30], Ran and miR-21 in esophageal cancer [31]. The gene discussed is RAN; the disease is osteosarcoma.