Evolving evidences indicate that P2X7 receptor plays a pivotal role in central nervous system pathology; genetic deletion and pharmacological blockade of P2X7 receptor provide neuroprotections toward various neurological disorders, such as ischemic stroke, neurotrauma, epilepsy, neuropathic pain, multiple sclerosis, and Alzheimer’s disease12, 13. Here, P2RX7 is linked to ischemic stroke.