TARDBP and amyotrophic lateral sclerosis: Immunoblotting of the Sarkosyl-insoluble fractions from FTLD and ALS cases using phosphospecific antibodies clearly demonstrated that hyperphosphorylated full-length TDP-43 of 45 kDa, smearing substances, and fragments at 18–25 and 35kDa are the major species of TDP-43 26, 31, 32.