The other TF from the most connected TF trio is the ZEB1 (Zinc Finger E-Box Binding Homeobox 1), a zinc finger transcription factor which is involved in cancer and in regulation of the expression of several genes (check the entry for [Uniprot:P37275] at http://www.uniprot.org), this gene have been related to muscle differentiation and myogenesis [45]. The gene discussed is ZEB1; the disease is cancer.