A recent meta-analysis showed that EGFR mutations in Asians with adenocarcinoma pathology is 47.9 % (1492 out of 3117 patients) [33], which is much higher than the reported incidence in European patients (10 %) [2, 34], Second, the results may be influenced by cut-off point selection for cytological tumor markers. Here, EGFR is linked to adenocarcinoma.