Overall, these studies suggest that relatives (parents, siblings and offspring) of long-lived subjects have a significant survival advantage, a higher probability to have been or to become long-lived and a lower risk to undergo to major age-related diseases, such as cardio- and cerebral-vascular diseases (CVD), diabetes, and cancer [6-17], associated with a favourable lipoprotein profile (larger HDL and LDL particle size) and increased homozygosity for the 405 valine allele (V allele) in the CETP gene (Cholesteryl Ester Transfer Protein) [18], and the −641 C allele in APOC3 gene [19]. The gene discussed is CETP; the disease is cancer.