The presence of the tyrosine kinase receptor on the cell membrane allowed the development of anti-c-kit antibodies for the histological identification of these cells.14 The absence or reduction in the number of ICC determines slow-wave abnormalities, causes decreased contractility of the smooth muscle cells, and decreases the transit rate of the intestinal content.15 The gene discussed is NTRK1; the disease is intrahepatic cholangiocarcinoma.