ESRRA and heart disorder: Although the binding interactions with nicotinic cholinergic receptors were expected, the interaction with ERRα has not been previously identified and is of interest given the apparent role of ERRs in regulating adipogenesis, energy homeostasis, diabetes, and heart disease (Bonnelye and Aubin 2013; Deblois and Giguère 2011; Ju et al. 2012; Ranhotra 2010; Villena and Kralli 2008).