So far several genetic associations between NTRK2 and psychopathology have been reported in the literature.31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 60, 61, 62 Given that dysregulation of emotional processes is a common characteristic of psychiatric disorders1 and that emotional arousal—specifically, the rating of emotionally arousing IAPS pictures—is reportedly altered in patients with psychiatric disorders,4, 5, 6, 7, 8, 9 we hypothesize that NTRK2 variants might be related to psychopathology through their influence on emotional processing. The gene discussed is NTRK2; the disease is psychiatric disorder.