In addition, a study also points to an involvement of genetic NTRK2 variants in brain imaging parameters, such as genotype-dependent differences in white-matter properties in depressed patients.41 In support of the genetic data, the expression pattern of NTRK2 in the brain, with high expression levels in different brain regions such as the occipital, temporal and frontal cerebral cortices, the putamen and the cerebellar cortex,18, 42, 43 also argues against a role for NTRK2 in a specific psychiatric disorder. This evidence concerns the gene NTRK2 and psychiatric disorder.