Consistent with the increased migration speed observed for both cell types on fibronectin, fibronectin increased Rac1 activation levels when compared to cells plated on laminin, which was accompanied by a FRET signal mainly at the cell borders (Fig 2A); this effect was slightly, but consistently, more pronounced in the Hinv/LE-cad tumor cells. The gene discussed is LAMB2; the disease is neoplasm.