FN1 and neoplasm: To summarize, these results in 2D and 3D matrices show that Linv/HE-cad OSCC cells migrate more directionally when plated using conditions similar to the epithelial and blood vessel basal lamina; whereas Hinv/LE-cad tumor cells switch from a collective to a faster single cell migration when transitioning from a laminin to a fibronectin rich connective tissue-like environment.