PTK2 and neoplasm: In the center of tumor, cells that appeared to have detached from the tumor island showed an increase in the staining of proteins related to cell-ECM adhesion, with paxillin showing increased labeling at the cell border, close to the ECM, while vinculin and FAK were observed at regions of membrane extensions of cells at the periphery of the tumor island, with some co-localization with actin.