Since the extracellular matrix composition can influence the migratory properties of various cell types, Linv/HE-cad (Cal27) or Hinv/LE-cad (SCC25) oral squamous cell carcinoma cell lines [20] were plated on 2D- Matrigel® (50μl/cm2), laminin (2μg/ml) or fibronectin (2μg/ml)-coated glass bottomed dishes and imaged for 24h. Here, LAMB2 is linked to oral cavity squamous cell carcinoma.