However, while we found that CD24 expression decreased with advanced tumor progression and tumor grade both in MMTV-PyMT and in Apc1572T/+ mice (Figs 1D, 1E and 2D; S1 and S2 Tables), the expression of CD24 in late stage human invasive carcinoma of the breast is significantly increased in comparison with non-tumor tissue [40]. Here, CD24 is linked to invasive breast carcinoma.