Gastrodin, 4-hydroxybenzyl alcohol, and 4-hydroxybenzaldehyde do not stimulate insulin secretion with a 2 mM glucose solution (low glucose) in insulinoma cells, but 20 μM 4-hydroxybenzyl alcohol and 20 μM 4-hydroxybenzaldehyde potentiated insulin secretion by 1.2 and 1.3-fold compared to that by the DMSO treatment, respectively, in a 20 mM glucose media (high glucose) (Figure 5). This evidence concerns the gene INS and pancreatic insulinoma.