For example, anti-platelet-derived growth factor (PDGF) aptamer E10010 combined with anti-VEGF antibody ranibizumab shows higher therapeutic potency than antibody alone for wet AMD treatment, and have passed phase II clinical evaluation and are waiting for phase III clinical trial now (clinical trial IDs NCT01944839 and NCT01940900) [18,19]. The gene discussed is VEGFA; the disease is wet macular degeneration.