HSPA5 and cancer: Since Normal cells are slightly sensitive to glucose starvation, both in untreated and FSK-treated samples [21], and since we were more interested in cancer cell survival mechanisms regulated by PKA activation, we tested only in Transformed cells UPR activation by Western blot analysis of two UPR hallmarks, the glucose-regulated protein 78 (Grp78 or Hspa5) and the C/EBP-homologous protein (CHOP or Ddit3).