POMC and obesity due to melanocortin 4 receptor deficiency: POMC/Pomc function also has broader application to common obesity; in both high fat diet-induced obesity and middle-age associated obesity, POMC neuron activity within the arcuate nucleus of the hypothalamus (ARC) is diminished, which has been proposed to have a causal role in the increased acquisition of body weight and adiposity [6], [7], [8].