One important discovery regarding the effect of nutrients on tissue-specific clock response is that in specific circumstances (the results can vary depending on the strain and age of mice, as well as the specific dietary components) a high fat diet can induce obesity simply by disrupting the circadian rhythmicity of energy intake, inducing increased energy intake during the normal resting phase [158], [159], [160]. The gene discussed is CLOCK; the disease is obesity due to melanocortin 4 receptor deficiency.