Considering that metabolic disease is associated with circadian disruption in humans [214], [215], [216], [217], [218], [219], [220] and that the clock uses nutrient input to set the local time, it is conceivable that both the timing and nutrient composition of one's diet might be key components of personalized medicine's future, in parallel to individual behavioral and genetic predisposition. This evidence concerns the gene CLOCK and Other metabolic disease.