NR1D1 and obesity due to melanocortin 4 receptor deficiency: The T minor allele of the REV-ERB-α rs2071427 polymorphism is associated with a higher BMI [238] while minor allele carriers for the REV-ERB-α rs2314339 polymorphism have a lower probability of abdominal obesity than non-carriers, as they have lower obesity parameters and lower waist circumference values.