This metabolic state has been shown to potentially provide cancer cells with an enhanced ability to withstand damage from RT [12], while obesity leads to a state of alteration of testosterone, estrogen, insulin, insulin-like growth factor-1 (IGF-1), and leptin, all hormones linked to prostate cancer, which could potentially interfere with hormonal therapy [13]. The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.