This observation is in accordance with several other previous studies.9,11 Neonato et al. (1999) reported that mutations in MBL2, which were associated with low levels of MBL, showed increased susceptibility to infections in their cohort of SCD patients.9 MBL is probably involved in the recognition of sickle RBC’s and removing them from the site of inflammation.9 However with low MBL levels in patients with mutant alleles; this process is hampered. This evidence concerns the gene MBL2 and infection.