A multicenter prospective study (Toronto, Canada and Milano, Italy), had determined the clinical features of 128 newborns born from 124 pregnancies in 112 women with positive anti-Ro/SSA antibodies, it found a high incidence of hematologic abnormalities (27%), the most frequent anomaly was neutropenia then anemia, thrombocytopenia was present in only 4% of cases. This evidence concerns the gene TRIM21 and Decreased total neutrophil count.