SPRY1 and neoplasm: Although we were unable to show whether there is an inverse correlation between membranous E-cadherin and Spry1 expression due to lack of available antibodies for co-immunostaining, we observed a variable increased expression of Fibronectin, a mesenchymal marker involved in tumor cell migration and metastasis47, concomitant with the high expression of Spry1 in some of TNBC (Supplemental Fig. S10).