TP53 and fibrosarcoma: Finally, we subjected G6PD-Tg mice and their WT littermates to 3-methyl-cholantrene (3MC), a potent carcinogen that induces fibrosarcomas in a p53 and p19Arf-dependent fashion28, 29, and G6PD-Tg mice developed tumors with the same kinetics as WT controls (Fig. 3i).