We selected SDF-1, since it is a key target of HIF-126, 27, 28, 29, 30, 31, 32, and the regulatory axis of SDF-1/CXCR4 is important for recruitment of CXCR4+ monocyte/macrophage into the SDF-1-rich tumor area. Here, CXCL12 is linked to neoplasm.