Increased blood creatine phosphokinase (CPK; 1.9 %), multi-organ failure (1.0 %), and sepsis (1.0 %) were the most commonly reported AEs regardless of relationship to daptomycin treatment, and the most common SAEs were multi-organ failure (1.0 %), sepsis (1.0 %), and septic shock (0.7 %). Here, PIK3C2A is linked to Sepsis.