CSF3 and myocardial infarction: However, G-CSF-based mobilization requires multiple doses over a number of days, is known to alter the function of the HSC niche as well as bone formation3, can cause bone pain and spleen enlargement and on rare occasions G-CSF results in splenic rupture, myocardial infarction or cerebral ischaemia (reviewed in refs 4, 5).