CD4 and Autoimmunity: Moreover, a combination of ins.mim.1=14E-21G-22E and ins.mim.4=14E-21E-22E resulted in significantly enhanced stimulation when compared with ins.mim.2=21G-22E and ins.mim.3=21E-22E) either in CD4+T cells from non-diabetic children with ongoing islet autoimmunity (Fig. 1d, P<0.01) or without autoimmunity (Supplementary Fig. 2).