CD4 and Autoimmunity: We identified enhanced frequencies of insulin mimetope-specific Foxp3+Tregs in non-diabetic children with longterm autoimmunity (long-term autoimmunity versus recent onset of autoimmunity: 11.7±0.9 versus 0.5±0.4 Foxp3+Tregs as a % of Tet+CD4+T cells, P<0.001, Fig. 3e), indicative of at least periods of successful ongoing immune regulation in such children.