INS and type 1 diabetes mellitus: To efficiently induce insulin-specific Foxp3+Tregs that could interfere with the development of T1D in NOD mice, we devised a strongly agonistic mimetope of the natural insulin-B-chain-epitope (21E-22E) with improved MHCII-binding7 and showed that its sub-immunogenic delivery promoted efficient Foxp3+Treg induction and T1D protection for 40 weeks and longer17.