Of interest, frequencies of insulin mimetope-specific Foxp3+Tregs were significantly lower in children with recent onset of autoimmunity than in children without autoimmunity (no autoimmunity versus recent onset of autoimmunity: 1.9±0.9 versus 0.5±0.4% of Tet+CD4+T cells, P<0.05, Fig. 3e). This evidence concerns the gene FOXP3 and Autoimmunity.