APOE and Alzheimer disease: In contrast to our examination of a cancer subnetworks, the prioritized subnetwork for the AD severe state centres around regulators in cytoskeletal regulation (ALB, APP), lipid transport (APOC2, APOE), immune-related responses (MYD88, TRAF1, TRAF6, TNFRSF19) and protein folding and degradation (CALR, PSMA1, UBC) (Figure 5C).