Failure of elimination of Aβ along capillary and arterial basement membranes with age could be the trigger for the amyloid cascade that drives the deposition of insoluble Aβ in plaques in the brain and furthermore may promote the propagation of tau pathology and neuro fibrillary tangles in the brain in Alzheimer’s disease [25]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.