Our results are supported by IHC studies by Sethi et al. that show vimentin overexpression at the invasive front of bone metastases of PCa patients and E-cadherin within the center of the lesion [69], and those of Bryden et al. who reported lower E-cadherin expression in poorly differentiated bone metastases than in more differentiated ones [70]. The gene discussed is VIM; the disease is posterior cortical atrophy.