CTSB and polycystic ovary syndrome: Interestingly, we found differential DNA methylation in all four genes that mapped to the chr 8p32.1 PCOS candidate locus (NEIL2, FDFT1, GATA4, and CTSB) and differential expression of FDF1 and CTSB. Further, we found differential gene expression and DNA methylation of one of the most promising functional candidate genes—ARL14EP, which maps to chr 11p14.1—but no changes in the FSHB expression or methylation in adipose tissue from women with PCOS.