One subfamily of Ntn hydrolases is represented by type 2 asparaginase proteins, which comprise three different types of enzymes: (i) asparaginases convert l-asparagine to l-aspartate, (ii) glycosylasparaginases are involved in the degradation of glycoproteins, as they remove N-acetylglucosamine attached to asparagine, and (iii) threonine aspartase 1 (Taspase1) is a threonine protease responsible for the activation of the mixed lineage leukemia (MLL) protein involved in childhood leukemias [6], and regulates transcription factor IIa (TFIIa) [7]. The gene discussed is TASP1; the disease is childhood leukemia.