In the present induced PE-like mouse model, established to address the role of TXA2 blockade in aspirin-mediated prevention of PE, pregnant WT mice demonstrated hypertension, imbalances in plasma prostanoid levels (elevated TXA2 level with no change in PGI2 level), increased TXAS in placenta, and decreased pup weight and size. The gene discussed is TBXAS1; the disease is hypertensive disorder.