COMT and depressive symptom measurement: However, there was no evidence for significant interactions of valence by COMT gene, Wilks’ λ > .99, F(2, 89) = .16, p = .85, η2 = .004, or valence by COMT gene by depression, Wilks’ λ > .99, F(2, 89) = .09, p = .92, η2 = .002.