HBEGF and cancer: Compared with the control mAb 2E12, mAb 2-108 successfully stained paraffin-embedded sections of cancer tumors of ovary, prostate, breast, uterus, stomach, and colon tissues, in which HB-EGF expression has been reported.(12,20–22,30–32) Conversely, each corresponding normal adjacent tissue showed little positive staining with mAb 2-108, suggesting that the positive signals are not due to nonspecific binding of mAb 2-108.