Cannabinoid receptor-1 (CNR1), CNR2, G-protein-coupled receptor 55 (GPR55), fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), cyclooxygenase -1 (COX1) and COX2 gene expression levels were ascertained to determine if expression levels correlated with the proliferative response of DLBCL cell lines to 2-AG. This evidence concerns the gene CNR1 and diffuse large B-cell lymphoma.