For example, in a mouse intraperitoneal model of ovarian cancer CDCP1 pro-survival signalling to PI3K/Akt is Src independent [9], whereas in animal models of vascular metastasis, proteolytic cleavage of CDCP1 induces Src phosphorylation of CDCP1−70 which complexes with activated β1-integrin to signal via Src to FAK-PI3K-Akt to suppress PARP-1-induced apoptosis [10, 22, 29]. Here, AKT1 is linked to ovarian carcinoma.