Upon chemoattraction into the tumor environment (47, 49, 123, 124) with a high concentration of colony-stimulating factor-1 (CSF-1), TGF-β1, macrophage inhibitory cytokine-1 (MIC-1), and IL-10, TAMs are polarized toward the M2 phenotype, subsequently inhibiting their phagocytic ability and enhancing their capacity to inhibit cytotoxic T-cell proliferation and increase the effect of Tregs (36). The gene discussed is TGFB1; the disease is neoplasm.