Immunosuppressive cytokines, including interleukin (IL)-6, IL-10, transforming growth factor-beta (TGF-β), and prostaglandin E2 (PGE2), as well as tumor-promoting cytokines, IL-1, and basic fibroblast growth factor (bFGF), are present in the GBM microenvironment and dampen the antitumor immune response (12–14). This evidence concerns the gene TGFB1 and neoplasm.