We have tried to incorporate these data in order to minimize the influence of additional factors on reliability prediction model to include in the biomarkers identified those that do not depend on renal clearance (MPCs and EMPs), were not associated with myocardial dysfunction (sRANKL/osteoprotegerin ratio), reflected the severity of endothelial dysfunction and coagulation (osteopontin, osteonectin). The gene discussed is SPARC; the disease is endothelial dysfunction.