The independent biomarker predictors of cumulative cardiovascular events in CHF patients obtained by multivariable Cox regression analyses adjusted heart failure medication were NT-pro-BNP, galectin-3, hs-CRP, osteoprotegerin, sRANKL/osteoprotegerin ratio, MPCs labeled CD14+CD309+Tie2+, and EMPs to CD14 + CD309+ MPCs ratio (Table 3). The gene discussed is TNFRSF11B; the disease is congestive heart failure.