In conclusion, we suggested that biomarker risk score for cumulative cardiovascular events, constructed by measurement of circulating NT-pro-BNP, galectin-3, hs-CRP, osteoprotegerin, CD31+/annexin V+ EMPs and EMPs/CD14 + CD309+ MPCs ratio, allowing reliably predict the probability survival of patients with CHF, regardless of age, gender, state of the contractile function of the left ventricle and the number of comorbidities. The gene discussed is NPPB; the disease is congestive heart failure.