Furthermore, this Grp170-expressing adenovirus combined with an adenovirus encoding melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), a cancer-specific, apoptosis-inducing gene (153), led to a synergistic systemic antitumor effect as shown by improved control of both treated and untreated prostate cancers (152). This evidence concerns the gene HYOU1 and Familial prostate cancer.