HYOU1 and viral infectious disease: Grp170 is inducible by glucose starvation, chronic anoxia/hypoxia, calcium depletion, low pH, a variety of reducing conditions, stress-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis, and viral infection that perturb the ER function (44, 51, 52), suggesting that Grp170 participates in quality control of protein folding in the ER.