HYOU1 and prostate carcinoma: Similarly, engineering of TRAMP-C2 mouse prostate cancer cells to secrete Grp170 profoundly enhanced tumor immunogenicity, indicated by increased levels of tumor-infiltrating CD8+ T cells, enhanced cytolytic activity, and improved control of distant tumors (104), suggesting that the induction or manipulation of large HSPs for secretion may help break immune tolerance to cancer cells.