In a separate study, Chen et al. reported that Grp170-HPV16 E749–57 peptide complex plus the TLR3 agonist polyinosinic-polycytidylic acid or poly(I:C), a synthetic analog of double-stranded RNA and a molecular pattern associated with viral infection, induced synergistically an immune response to cervical cancer in mice (156). The gene discussed is HYOU1; the disease is viral infectious disease.